Endocannabinoid Degradation and Human Fertility
نویسندگان
چکیده
Anandamide (AEA) impairs mouse pregnancy and embryo development. Here, we overview the role of AEA in sexual function, focusing on AEA degradation during human pregnancy. Human peripheral lymphocytes express the AEA-hydrolyzing enzyme fatty acid amide hydrolase (FAAH), which decreases in miscarrying women. FAAH is regulated by progesterone and Th1/Th2 cytokines, whereas the AEA transporter and the AEA binding cannabinoid receptors are not affected. Taken together, our results appear to add the endocannabinoids to the hormone-cytokine array
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